Longitudinal Assessment of Depressive Symptoms After Sport-Related Concussion in a Cohort of High School Athletes

Background: The long-term effect of sport-related concussion on mood in adolescent athletes is largely unknown. Hypothesis: Longitudinal measures of depression will worsen acutely after sport-related concussion and improve with concussion symptom resolution. Study Design: Prospective cohort study. Level of Evidence: Level 3. Methods: A population-based sample of 2160 high school athletes from 31 urban, suburban, and rural high schools completed preseason baseline concussion symptom evaluation and Patient Health Questionnaire-9 (PHQ-9) assessments over 2 years. Athletic trainers recorded onset of sport-related concussion, and concussed athletes completed the PHQ-9 assessment within 24 to 72 hours, 7 days, date of return to sport, 3 months, 6 months, and 12 months after sport-related concussion. Scores at each time point were compared to baseline with mixed-effects models and repeated-measures analysis of variance. Sex-based differences were assessed using mixed-effect models. Results: Of the 2160 athletes enrolled in the study, 125 (5.8%; 80 males, 45 females) sustained a sport-related concussion. PHQ-9 scores worsened from baseline at 24 to 72 hours (+1.05; 95% CI, 0.26-1.84; P = 0.003) and 7 days (+0.91; 95% CI, 0.23-1.60; P = 0.006). However, PHQ-9 scores improved from baseline to date of return to sport (-1.38; 95% CI, -2.20 to -0.55; P < 0.001), 3 months (-1.08; 95% CI, -1.88 to -0.28; P = 0.003), 6 months (-1.19; 95% CI, -2.04 to -0.34; P = 0.001), and 12 months after sport-related concussion (-0.76; 95% CI, -1.43 to -0.08; P = 0.028). Female athletes reported more severe concussion symptoms 24 to 72 hours after sport-related concussion compared with male athletes (female, 20.5 [interquartile range (IQR), 10.0-36.2]; male, 9.0 [IQR, 4.0-19.5]; P = 0.003). Neither PHQ-9 scores nor change in PHQ-9 scores differed between male and female athletes at any time point. Conclusion: Sport-related concussion did not worsen longitudinal measures of depressed mood in this cohort of high school athletes.

Automated summary

This prospective cohort study followed 2160 high school athletes over 2 years and found that sport-related concussion did not significantly worsen depression in adolescent athletes, and that depression symptoms improved after concussion symptom resolution. Female athletes reported more severe symptoms in the first few days after concussion compared to male athletes.