期刊
OPEN FORUM INFECTIOUS DISEASES
卷 7, 期 10, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofaa415
关键词
mycobacterial infections; Mycobacterium abscessus; nontuberculous mycobacteria; omadacycline
资金
- National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health [T32 AI007387]
- NIAID [K08 AI141740, L30 AI120170, P30 AI060354]
- Dr. Lynne Reid/Drs. Eleanor and Miles Shore Fellowship at Harvard Medical School
- Burke Global Health Fellowship at the Harvard Global Health Institute
- Harvard University Center for AIDS Research
Background. Omadacycline is an aminomethylcycline antimicrobial approved by the US Food and Drug Administration in 2018 for community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. It has in vitro activity against nontuberculous mycobacteria, including Mycobacterium abscessus complex, but clinical data for this indication are lacking. Methods. Omadacycline use was reviewed at an 804-bed academic medical center. Patients were included if they received omadacycline for culture-proven M abscessus disease in 2019. Results. Four patients received omadacycline for the treatment of culture-positive M abscessus disease in 2019. Two patients had cutaneous disease, 1 had pulmonary disease, and 1 had osteomyelitis and bacteremia. The patients received omadacycline for a median duration of 166 days (range, 104-227) along with a combination of other antimicrobial agents. Omadacycline-containing regimens were associated with a clinical cure in 3 of 4 patients, with 1 patient improving on ongoing treatment. Omadacycline's tolerability was acceptable for patients with M abscessus disease, with 1 patient discontinuing therapy in month 6 due to nausea. Conclusions. Omadacycline is a novel oral option for the treatment of M abscessus disease, for which safe and effective options are needed. Although this case series is promising, further data are required to determine omadacycline's definitive role in the treatment of M abscessus disease.
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