期刊
PHARMACEUTICS
卷 12, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics12100980
关键词
extracellular vesicles; nucleic acid delivery; gene therapy; cancer
资金
- VALERE: Vanvitelli per la Ricerca
- Campania Regional Government Technology Platform Lotta alle Patologie Oncologiche [iCURE-B21C17000030007]
- Campania Regional Government FASE2: IDEAL
- MIUR
- Proof of Concept [EPICUREPOC01_00043-B64I19000290008]
- P.O.R. CAMPANIA FSE 2014/2020 ASSE [III-B27D18001070006]
- [AIRC-17217]
Extracellular vesicles (EVs) are sophisticated and sensitive messengers released by cells to communicate with and influence distant and neighboring cells via selective transfer of bioactive content, including protein lipids and nucleic acids. EVs have therefore attracted broad interest as new and refined potential therapeutic systems in many diseases, including cancer, due to their low immunogenicity, non-toxicity, and elevated bioavailability. They might serve as safe and effective vehicles for the transport of therapeutic molecules to specific tissues and cells. In this review, we focus on EVs as a vehicle for gene therapy in cancer. We describe recent developments in EV engineering to achieve efficient intracellular delivery of cancer therapeutics and avoid off-target effects, to provide an overview of the potential applications of EV-mediated gene therapy and the most promising biomedical advances.
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