期刊
WORLD JOURNAL OF STEM CELLS
卷 12, 期 9, 页码 952-965出版社
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4252/wjsc.v12.i9.952
关键词
Stem cells; Mechanical loading; Tendon repair; Mechanotransduction
资金
- National Natural Science Foundation of China [81871848, 81702171]
- Shenzhen Double Chain Project for Innovation and Development Industry [201806081018272960]
Tendon is a mechanosensitive tissue that transmits force from muscle to bone. Physiological loading contributes to maintaining the homeostasis and adaptation of tendon, but aberrant loading may lead to injury or failed repair. It is shown that stem cells respond to mechanical loading and play an essential role in both acute and chronic injuries, as well as in tendon repair. In the process of mechanotransduction, mechanical loading is detected by mechanosensors that regulate cell differentiation and proliferationviaseveral signaling pathways. In order to better understand the stem-cell response to mechanical stimulation and the potential mechanism of the tendon repair process, in this review, we summarize the source and role of endogenous and exogenous stem cells active in tendon repair, describe the mechanical response of stem cells, and finally, highlight the mechanotransduction process and underlying signaling pathways.
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