期刊
FRONTIERS IN ONCOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2020.01584
关键词
microbiota; 16S rRNA; lung cancer; bronchoalveolar lavage fluid; cancerous lung and the contralateral non-cancerous lung
类别
资金
- Beijing Natural Science Foundation [7182029, 7162038]
- Capital's Funds for Health Improvement and Research [2020-4-1028]
- Beijing Municipal Science & Technology Commission [Z181100001718104]
- Beijing Hospitals Authority Youth Programme [QML20191105]
- Beijing Municipal Administration of Hospitals' Youth Program [QML20161101]
- Peking University Medicine Fund of Fostering Young Scholars' Scientific & Technological Innovation [BMU2020PYB017]
- Science Foundation of Peking University Cancer Hospital [18-02, 2020-4]
Background The functional role of lung microbiota has attracted an accumulating attention recently, but the profile and functional role of the lung microbiota in patients with lung cancer remained largely unknown. Methods To evaluate the association of the microbiota with lung cancer, we performed comparative analysis of the lung microbiota using 16S rRNA amplicon sequencing approach in the paired bronchoalveolar lavage fluid (BALF) samples (paired samples from cancerous lung and the contralateral non-cancerous lung) from 50 cancer patients with unilateral lobar masses. Results We found that the relative abundance of phylum Tenericutes, its class Mollicutes, its order Entomoplasmatales, its family Spiroplasmataceae, and its genusSpiroplasmawas significantly increased in cancerous lung, but the relative abundance of phylum Bacteroidetes, its class Bacteroidia, and its order Bacteroidales was significantly decreased in cancerous lung. In addition, the relative abundance of family Leuconostocaceae and its genusWeissellawas significantly increased in cancerous lung. Conclusion Our findings provide insights into a change of lung microbiota community associated with the development of lung cancer.
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