期刊
CELLS
卷 9, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/cells9092022
关键词
ubiquitin; autophagy; neurodegenerative diseases; ubiquitin-proteasome system; autophagy-lysosome pathway
类别
资金
- Japan Society for the Promotion of Science [18K07505, 18K07371, 17H03553]
- Shimizu Foundation for Immunology and Neuroscience
- Grants-in-Aid for Scientific Research [18K07371, 17H03553, 18K07505] Funding Source: KAKEN
Ubiquitin signals play various roles in proteolytic and non-proteolytic functions. Ubiquitin signals are recognized as targets of the ubiquitin-proteasome system and the autophagy-lysosome pathway. In autophagy, ubiquitin signals are required for selective incorporation of cargoes, such as proteins, organelles, and microbial invaders, into autophagosomes. Autophagy receptors possessing an LC3-binding domain and a ubiquitin binding domain are involved in this process. Autophagy activity can decline as a result of genetic variation, aging, or lifestyle, resulting in the onset of various neurodegenerative diseases. This review summarizes the selective autophagy of neurodegenerative disease-associated protein aggregates via autophagy receptors and discusses its therapeutic application for neurodegenerative diseases.
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