期刊
CELLS
卷 9, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/cells9102238
关键词
circular RNAs; circRNAs; microRNAs; RBPs; sponge; expression; biomarkers; therapy; schizophrenia
类别
资金
- Russian Foundation of Basic Research [RFBR 18-29-23020 mk, RFBR 17-29-02518 ofi-m]
- Russian Scientific Foundation (RSF) [20-15-00299]
- Russian Science Foundation [20-15-00299] Funding Source: Russian Science Foundation
Circular RNAs (circRNAs) are endogenous, single-stranded, most frequently non-coding RNA (ncRNA) molecules that play a significant role in gene expression regulation. Circular RNAs can affect microRNA functionality, interact with RNA-binding proteins (RBPs), translate proteins by themselves, and directly or indirectly modulate gene expression during different cellular processes. The affected expression of circRNAs, as well as their targets, can trigger a cascade of events in the genetic regulatory network causing pathological conditions. Recent studies have shown that altered circular RNA expression patterns could be used as biomarkers in psychiatric diseases, including schizophrenia (SZ); moreover, circular RNAs together with other cell molecules could provide new insight into mechanisms of this disorder. In this review, we focus on the role of circular RNAs in the pathogenesis of SZ and analyze their biomarker and therapeutic potential in this disorder.
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