期刊
CELLS
卷 9, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/cells9102160
关键词
microRNA; tuberculosis; diagnosis; biomarker; pathogenesis; latent infection; disease progression; response to therapy; innate immunity; apoptosis; autophagy
类别
资金
- European Commission's Horizon 2020 research and innovation program [825931]
- H2020 Societal Challenges Programme [825931] Funding Source: H2020 Societal Challenges Programme
Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the most lethal infectious diseases with estimates of approximately 1.4 million human deaths in 2018. M. tuberculosis has a well-established ability to circumvent the host immune system to ensure its intracellular survival and persistence in the host. Mechanisms include subversion of expression of key microRNAs (miRNAs) involved in the regulation of host innate and adaptive immune response against M. tuberculosis. Several studies have reported differential expression of miRNAs during active TB and latent tuberculosis infection (LTBI), suggesting their potential use as biomarkers of disease progression and response to anti-TB therapy. This review focused on the miRNAs involved in TB pathogenesis and on the mechanism through which miRNAs induced during TB modulate cell antimicrobial responses. An attentive study of the recent literature identifies a group of miRNAs, which are differentially expressed in active TB vs. LTBI or vs. treated TB and can be proposed as candidate biomarkers.
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