期刊
CELLS
卷 9, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/cells9091961
关键词
actin ring; actomyosin cytoskeleton; axon initial segment; axon growth; axon regeneration; growth cone; non-muscle myosin II
类别
资金
- FEDER-Fundo Europeu de Desenvolvimento Regional through the NORTE 2020-Norte Portugal Regional Operational Programme, Portugal 2020
- Portuguese funds through FCT-Fundacao para a Ciencia e Tecnologia/Ministerio da Ciencia, Tecnologia e Ensino Superior [NORTE-01-0145-FEDER-028623 (PTDC/MED-NEU/28623/2017)]
- FCT [SFRH/BPD/114912/2016]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/114912/2016] Funding Source: FCT
By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that hold unique contractile properties. Their dynamic nature is essential for neuronal biology including the establishment of polarity, growth cone formation and motility, axon growth during development (and axon regeneration in the adult), radial and longitudinal axonal tension, and synapse formation and function. In this review, we discuss the current knowledge on the spatial distribution and function of the actomyosin cytoskeleton in different axonal compartments. We highlight some of the apparent contradictions and open questions in the field, including the role of NMII in the regulation of axon growth and regeneration, the possibility that NMII structural arrangement along the axon shaft may control both radial and longitudinal contractility, and the mechanism and functional purpose underlying NMII enrichment in the axon initial segment. With the advances in live cell imaging and super resolution microscopy, it is expected that in the near future the spatial distribution of NMII in the axon, and the mechanisms by which it participates in axonal biology will be further untangled.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据