期刊
CANCERS
卷 12, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/cancers12092599
关键词
cholangiocarcinoma; biliary tract cancers; molecular profiling; driver mutations; targeted therapy; immunotherapy
类别
Simple Summary The incidence of cholangiocarcinomas is rising. The prognosis of this heterogeneous group of tumors remains poor. Standard chemotherapy options are limited and frequently not effective. Recently, extensive molecular profiling identified key actionable drivers leading to successful biomarker-selected clinical trials. A number of novel targeted therapy drugs and immune checkpoint inhibitors are under investigation. In this review we summarized recent progress in the systemic treatment of cholangiocarcinomas, highlighting biomarkers and therapies in ongoing early-phase clinical trials. Cholangiocarcinomas (CCAs) comprise of a heterogeneous group of cancers arising in the biliary tract (intrahepatic or iCCA, perihilar or pCCA and distal or dCCA; the latter are known under the collective term of eCCA), each subtype having its own particularities in carcinogenesis, management and prognosis. The increasing incidence in recent decades, limited treatment options and high mortality rates, even in the early stages, have led to an imperious need for more in-depth understanding and development of tailored treatments for this type of aggressive tumour. The wide use of molecular profiling has increased the understanding of biology and identified key molecular drivers, for example, IDH1 mutations or FGFR2 fusions for iCCA, or BRAF mutations in eCCA. Most recently, the FDA approved pemigatinib, an FGFR inhibitor and ivosidenib, an IDH1 inhibitor, but even though progress has been made to better understand the mechanisms of tumorigenesis, genetic make-up, and tumour resistance to standard chemotherapy and targeted therapies, cholangiocarcinomas still represent an important challenge in the daily clinical practice of oncology. The purpose of this review is to highlight the recent progress in the systemic treatment of advanced/metastatic CCAs with a focus on targeted drugs and their biomarkers currently evaluated in early-phase clinical trials.
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