相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Revving the CAR-Combination strategies to enhance CAR T cell effectiveness
Rajat Bansal et al.
BLOOD REVIEWS (2021)
HITM-SIR: phase Ib trial of intraarterial chimeric antigen receptor T-cell therapy and selective internal radiation therapy for CEA+ liver metastases
Steven C. Katz et al.
CANCER GENE THERAPY (2020)
Determinants of response and resistance to CAR T cell therapy
Stefanie Lesch et al.
SEMINARS IN CANCER BIOLOGY (2020)
Enhancing Chimeric Antigen Receptor T-Cell Efficacy in Solid Tumors
Giovanni Fuca et al.
CLINICAL CANCER RESEARCH (2020)
Chimeric antigen receptor T cells in solid tumors: a war against the tumor microenvironment
Zijun Zhao et al.
SCIENCE CHINA-LIFE SCIENCES (2020)
Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma
Dongrui Wang et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment
Aleksei Titov et al.
CANCERS (2020)
Chimeric Antigen Receptor-Glypican-3 T-Cell Therapy for Advanced Hepatocellular Carcinoma: Results of Phase I Trials
Donghua Shi et al.
CLINICAL CANCER RESEARCH (2020)
CARs: Beyond T Cells and T Cell-Derived Signaling Domains
Nico M. Sievers et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype
Mary S. Pampusch et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2020)
Transposon-Based CAR T Cells in Acute Leukemias: Where Are We Going?
Chiara F. Magnani et al.
CELLS (2020)
Chimeric Antigen Receptor Therapy: How Are We Driving in Solid Tumors?
Uri Greenbaum et al.
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2020)
The old CEACAMs find their new role in tumor immunotherapy
Zi-Wen Han et al.
INVESTIGATIONAL NEW DRUGS (2020)
Anti-PSMA CAR-Engineered NK-92 Cells: An Off-the-Shelf Cell Therapy for Prostate Cancer
Isabella Monia Montagner et al.
CELLS (2020)
Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors
Emmanuel Donnadieu et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2020)
Metabolic regulation of CAR T cell function by the hypoxic microenvironment in solid tumors
Anna Schurich et al.
IMMUNOTHERAPY (2019)
Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor-transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma
Stephanie L. Goff et al.
JOURNAL OF IMMUNOTHERAPY (2019)
Chimeric Antigen Receptor T Cell Therapy for Solid Tumors: Current Status, Obstacles and Future Strategies
Benjamin Heyman et al.
CANCERS (2019)
Ligand-inducible, prostate stem cell antigen (PSCA)-directed GoCAR-T cells in advanced solid tumors: Preliminary results with cyclophosphamide (Cy) ± fludarabine (Flu) lymphodepletion (LD).
Carlos Roberto Becerra et al.
JOURNAL OF CLINICAL ONCOLOGY (2019)
Phase I trial of Claudin 18.2-specific chimeric antigen receptor T cells for advanced gastric and pancreatic adenocarcinoma.
Xianbao Zhan et al.
JOURNAL OF CLINICAL ONCOLOGY (2019)
Regional delivery of mesothelin-targeted CAR T cells for pleural cancers: Safety and preliminary efficacy in combination with anti-PD-1 agent.
Prasad S. Adusumilli et al.
JOURNAL OF CLINICAL ONCOLOGY (2019)
The Role of the Cell Surface Mucin MUC1 as a Barrier to Infection and Regulator of Inflammation
Poshmaal Dhar et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)
Limitations in the Design of Chimeric Antigen Receptors for Cancer Therapy
Stefan Stoiber et al.
CELLS (2019)
SO-009Phase 1 studies assessing the safety and clinical activity of autologous and allogeneic NKG2D-based CAR-T therapy in metastatic colorectal cancer
E Van Cutsem et al.
ANNALS OF ONCOLOGY (2019)
Chimeric Antigen Receptor-T Cells for Targeting Solid Tumors: Current Challenges and Existing Strategies
Lorraine Springuel et al.
BIODRUGS (2019)
CAR T cells for brain tumors: Lessons learned and road ahead
David Akhavan et al.
IMMUNOLOGICAL REVIEWS (2019)
CSPG4-Specific CAR T Cells for High-Risk Childhood B Cell Precursor Leukemia
Dennis C. Harrer et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers
Andrew R. Haas et al.
MOLECULAR THERAPY (2019)
Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?
Rui-Mei Feng et al.
CANCER COMMUNICATIONS (2019)
CAR-T Engineering: Optimizing Signal Transduction and Effector Mechanisms
Emiliano Roselli et al.
BIODRUGS (2019)
An update on emerging drugs in osteosarcoma: towards tailored therapies?
Claudia Maria Hattinger et al.
EXPERT OPINION ON EMERGING DRUGS (2019)
Clinical lessons learned from the first leg of the CAR T cell journey
Robbie G. Majzner et al.
NATURE MEDICINE (2019)
Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance
Manuel Wiesinger et al.
CANCERS (2019)
Cancer-associated mucins: role in immune modulation and metastasis
Rakesh Bhatia et al.
CANCER AND METASTASIS REVIEWS (2019)
Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Stephen J. Schuster et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Chimeric Antigen Receptor T-cell (CAR T) Therapy for Hematologic and Solid Malignancies: Efficacy and Safety-A Systematic Review with Meta-Analysis
Wen-Liang Yu et al.
CANCERS (2019)
CAR T Cells: A Snapshot on the Growing Options to Design a CAR
Astrid Holzinger et al.
HEMASPHERE (2019)
Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerations
Robert Weinkove et al.
CLINICAL & TRANSLATIONAL IMMUNOLOGY (2019)
Genetically engineered T cells for cancer immunotherapy
Dan Li et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)
Phase I study of chimeric antigen receptor modified T cells in treating HER2-positive advanced biliary tract cancers and pancreatic cancers
Kaichao Feng et al.
PROTEIN & CELL (2018)
Latest developments in MUC1 immunotherapy
Joyce Taylor-Papadimitriou et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2018)
Building a Safer and Faster CAR: Seatbelts, Airbags, and CRISPR
Miguel-Angel Perales et al.
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2018)
Nonviral RNA chimeric antigen receptor-modified T cells in patients with Hodgkin lymphoma
Jakub Svoboda et al.
BLOOD (2018)
Antigenic targets of CAR T Cell Therapy. A retrospective view on clinical trials
Fatemeh Arabi et al.
EXPERIMENTAL CELL RESEARCH (2018)
Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial
Gregory L. Beatty et al.
GASTROENTEROLOGY (2018)
Chimeric Antigen Receptors in Different Cell Types: New Vehicles Join the Race
Dennis C. Harrer et al.
HUMAN GENE THERAPY (2018)
BRAF and MEK Inhibitors Influence the Function of Reprogrammed T Cells: Consequences for Adoptive T-Cell Therapy
Jan Doerrie et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward
Jian Li et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)
In Vivo Expansion and Antitumor Activity of Coinfused CD28-and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia
Zhi Cheng et al.
MOLECULAR THERAPY (2018)
Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication
Christopher C. Kloss et al.
MOLECULAR THERAPY (2018)
A Rapamycin-Activated Caspase 9-Based Suicide Gene
Maria Stavrou et al.
MOLECULAR THERAPY (2018)
IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor
Keishi Adachi et al.
NATURE BIOTECHNOLOGY (2018)
Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
Joseph A. Fraietta et al.
NATURE MEDICINE (2018)
CAR T-Cell Therapy in Large B-Cell Lymphoma
Alfonso Quintas-Cardama
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Chimeric Antigen Receptor Therapy
Carl H. June et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia
Jae H. Park et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
S. L. Maude et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Lymphocyte apheresis for chimeric antigen receptor T-cell manufacturing in children and young adults with leukemia and neuroblastoma
Francesco Ceppi et al.
TRANSFUSION (2018)
Clinical significance of TM4SF1 as a tumor suppressor gene in gastric cancer
Xing-Chun Peng et al.
CANCER MEDICINE (2018)
Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma
Carter M. Suryadevara et al.
ONCOIMMUNOLOGY (2018)
CD133-directed CAR T cells for advanced metastasis malignancies: A phase I trial
Yao Wang et al.
ONCOIMMUNOLOGY (2018)
Cytokine release syndrome
Alexander Shimabukuro-Vornhagen et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)
Role of transmembrane glycoprotein mucin 1 (MUC1) in various types of colorectal cancer and therapies: Current research status and updates
Mei Guo et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Freddie Bray et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2018)
A phase I study of adoptive immunotherapy for advanced ROR1+malignancies with defined subsets of autologous T cells expressing a ROR1-specific chimeric antigen receptor (ROR1-CAR)
Jennifer M. Specht et al.
CANCER RESEARCH (2018)
A Cancer Research UK phase I trial of anti-GD2 chimeric antigen receptor (CAR) transduced T-cells (1RG-CART) in patients with relapsed or refractory neuroblastoma
Karin Straathof et al.
CANCER RESEARCH (2018)
Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas
Yibo Yin et al.
MOLECULAR THERAPY-ONCOLYTICS (2018)
Mucins and Their Role in Shaping the Functions of Mucus Barriers
C. E. Wagner et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 34 (2018)
Non-viral therapeutic cell engineering with the Sleeping Beauty transposon system
Michael Hudecek et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2018)
A Review on Electroporation-Based Intracellular Delivery
Junfeng Shi et al.
MOLECULES (2018)
33rd Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2018) Abstracts
[Anonymous]
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)
Phase I Study of Chimeric Antigen Receptor-Modified T Cells in Patients with EGFR-Positive Advanced Biliary Tract Cancers
Yelei Guo et al.
CLINICAL CANCER RESEARCH (2018)
Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis
B. Benzon et al.
PROSTATE CANCER AND PROSTATIC DISEASES (2017)
Transposons: Moving Forward from Preclinical Studies to Clinical Trials
Jaitip Tipanee et al.
HUMAN GENE THERAPY (2017)
Redirecting T Cells to Glypican-3 with 4-1BB Zeta Chimeric Antigen Receptors Results in Th1 Polarization and Potent Antitumor Activity
Wenpeng Li et al.
HUMAN GENE THERAPY (2017)
Cocktail treatment with EGFR-specific and CD133-specific chimeric antigen receptor-modified T cells in a patient with advanced cholangiocarcinoma
Kai-chao Feng et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)
Chimeric antigen receptor T cells: a novel therapy for solid tumors
Shengnan Yu et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2017)
Possible Compartmental Cytokine Release Syndrome in a Patient With Recurrent Ovarian Cancer After Treatment With Mesothelin-targeted CAR-T Cells
Janos L. Tanyi et al.
JOURNAL OF IMMUNOTHERAPY (2017)
Elutriated lymphocytes for manufacturing chimeric antigen receptor T cells
David F. Stroncek et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2017)
Tumor B7-H3 (CD276) expression and smoking history in relation to lung adenocarcinoma prognosis
Kentaro Inamura et al.
LUNG CANCER (2017)
Phase I Escalating-Dose Trial of CAR-T Therapy Targeting CEA+ Metastatic Colorectal Cancers
Chengcheng Zhang et al.
MOLECULAR THERAPY (2017)
CAR T Cells Administered in Combination with Lymphodepletion and PD-1 Inhibition to Patients with Neuroblastoma
Andras Heczey et al.
MOLECULAR THERAPY (2017)
Regulated Expansion and Survival of Chimeric Antigen Receptor-Modified T Cells Using Small Molecule-Dependent Inducible MyD88/CD40
Aaron E. Foster et al.
MOLECULAR THERAPY (2017)
A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma
Donald M. O'Rourke et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma
Khun Visith Keu et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells
Thomas Shum et al.
CANCER DISCOVERY (2017)
Study protocol for THINK: a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types
Caroline Lonez et al.
BMJ OPEN (2017)
Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment
Zhenguang Wang et al.
PROTEIN & CELL (2017)
Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer
Julia Tchou et al.
CANCER IMMUNOLOGY RESEARCH (2017)
New Chimeric Antigen Receptor Design for Solid Tumors
Yuedi Wang et al.
FRONTIERS IN IMMUNOLOGY (2017)
Anti-GPEC3-CAR T Cells Suppress the Growth of Tumor Cells in Patient-Derived Xenogratfts of Hepatocelluar Carcinoma
Zhiwu Jiang et al.
FRONTIERS IN IMMUNOLOGY (2017)
Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications
Hamid R. Mirzaei et al.
FRONTIERS IN IMMUNOLOGY (2017)
PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells
Xinru Wei et al.
ONCOIMMUNOLOGY (2017)
HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma A Phase 1 Dose-Escalation Trial
Nabil Ahmed et al.
JAMA ONCOLOGY (2017)
Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer
Kristen M. Hege et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2017)
Regional Delivery of Chimeric Antigen Receptor (CAR) T-Cells for Cancer Therapy
Praveen Sridhar et al.
CANCERS (2017)
Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The Rotation Model
Endang R. Purba et al.
CELLS (2017)
A phase I study of anti-GPC3 chimeric antigen receptor modified T cells (GPC3 CAR-T) in Chinese patients with refractory or relapsed GPC3+hepatocellular carcinoma (r/r GPC3+HCC).
Bo Zhai et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
Expansion of HER2-CAR T cells after lymphodepletion and clinical responses in patients with advanced sarcoma.
Meenakshi Hegde et al.
JOURNAL OF CLINICAL ONCOLOGY (2017)
CAR T cells targeting solid tumors: carcinoembryonic antigen (CEA) proves to be a safe target
Astrid Holzinger et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)
The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity
Fiona C. Thistlethwaite et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2017)
RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma
Dennis C. Harrer et al.
BMC CANCER (2017)
Vaccination Targeting Native Receptors to Enhance the Function and Proliferation of Chimeric Antigen Receptor (CAR)-Modified T Cells
Miyuki Tanaka et al.
CLINICAL CANCER RESEARCH (2017)
HITM-SIR: Phase Ib trial of CAR-T hepatic artery infusions and selective internal radiation therapy for liver metastases
Steven C. Katz et al.
CANCER RESEARCH (2017)
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature
Steven Seaman et al.
CANCER CELL (2017)
Recent clinical trials utilizing chimeric antigen receptor T cells therapies against solid tumors
Shuanglin Han et al.
CANCER LETTERS (2017)
The Principles of Engineering Immune Cells to Treat Cancer
Wendell A. Lim et al.
CELL (2017)
The growing world of CAR T cell trials: a systematic review
Astrid Holzinger et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2016)
A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors
Xiaojun Liu et al.
CANCER RESEARCH (2016)
Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy
Elodie Picarda et al.
CLINICAL CANCER RESEARCH (2016)
Combining a chimeric antigen receptor and a conventional T-cell receptor to generate T cells expressing two additional receptors (TETARs) for a multi-hit immunotherapy of melanoma
Ugur Uslu et al.
EXPERIMENTAL DERMATOLOGY (2016)
Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells
Omkar U. Kawalekar et al.
IMMUNITY (2016)
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
Andrea Schietinger et al.
IMMUNITY (2016)
Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives
Jose Eduardo Vargas et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2016)
GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade
Tessa Gargett et al.
MOLECULAR THERAPY (2016)
Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy
Christine E. Brown et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells
Lenka V. Hurton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Phase I Trial of Anti-PSMA Designer CAR-T Cells in Prostate Cancer: Possible Role for Interacting Interleukin 2-T Cell Pharmacodynamics as a Determinant of Clinical Response
Richard P. Junghans et al.
PROSTATE (2016)
Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells
Fengtao You et al.
SCIENCE CHINA-LIFE SCIENCES (2016)
Chimeric antigen receptor-modified T cells for the immunotherapy of patients with EGFR-expressing advanced relapsed/refractory non-small cell lung cancer
Kaichao Feng et al.
SCIENCE CHINA-LIFE SCIENCES (2016)
IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia
Aizhang Xu et al.
CELL AND BIOSCIENCE (2016)
Improving Adoptive T Cell Therapy: The Particular Role of T Cell Costimulation, Cytokines, and Post-Transfer Vaccination
Anke Redeker et al.
FRONTIERS IN IMMUNOLOGY (2016)
Anti-mesothelin chimeric antigen receptor T cells in patients with epithelial ovarian cancer.
Janos Laszlo Tanyi et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
Multiplexed Engineering of CD19CAR T Cells for Post-Transplant Consolidative Immunotherapy
Corinne Summers et al.
BLOOD (2016)
Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity
Nicole E. Scharping et al.
VACCINES (2016)
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells
Zeguo Zhao et al.
CANCER CELL (2015)
Stability and activity of MCSP-specific chimeric antigen receptors (CARs) depend on the scFv antigen-binding domain and the protein backbone
Christian Krug et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)
Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
Albert Lo et al.
CANCER RESEARCH (2015)
Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma
Christine E. Brown et al.
CLINICAL CANCER RESEARCH (2015)
Phase I Hepatic Immunotherapy for Metastases Study of Intra-Arterial Chimeric Antigen Receptor-Modified T-cell Therapy for CEA+ Liver Metastases
Steven C. Katz et al.
CLINICAL CANCER RESEARCH (2015)
Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma
Nabil Ahmed et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer
Mythili Koneru et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2015)
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
Adrienne H. Long et al.
NATURE MEDICINE (2015)
Tissue-based map of the human proteome
Mathias Uhlen et al.
SCIENCE (2015)
Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma
Laura A. Johnson et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells
Matthew J. Frigault et al.
CANCER IMMUNOLOGY RESEARCH (2015)
Designing CAR T cells for glioblastoma
Marcela V. Maus
ONCOIMMUNOLOGY (2015)
IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumors in vivo
Mythili Koneru et al.
ONCOIMMUNOLOGY (2015)
Autologous HER2 CMV bispecific CAR T cells are safe and demonstrate clinical benefit for glioblastoma in a Phase I trial.
Nabil Ahmed et al.
Journal for ImmunoTherapy of Cancer (2015)
Overcoming the toxicity hurdles of genetically targeted T cells
Monica Casucci et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2015)
NKG2D signaling in cancer immunosurveillance
Alejandro Lopez-Soto et al.
INTERNATIONAL JOURNAL OF CANCER (2015)
T Cells Bearing a Chimeric Antigen Receptor against Prostate-Specific Membrane Antigen Mediate Vascular Disruption and Result in Tumor Regression
Stephen P. Santoro et al.
CANCER IMMUNOLOGY RESEARCH (2015)
TGF-beta Activation and Function in Immunity
Mark A. Travis et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)
Neutrophil:lymphocyte ratios and serum cytokine changes after hepatic artery chimeric antigen receptor-modified T-cell infusions for liver metastases
A. Saied et al.
CANCER GENE THERAPY (2014)
Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma
Markus Chmielewski et al.
IMMUNOLOGICAL REVIEWS (2014)
Chimeric antigen receptors for the adoptive T cell therapy of hematologic malignancies
Marco L. Davila et al.
INTERNATIONAL JOURNAL OF HEMATOLOGY (2014)
Anti-melanoma activity of T cells redirected with a TCR-like chimeric antigen receptor
Ge Zhang et al.
SCIENTIFIC REPORTS (2014)
Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies
Gregory L. Beatty et al.
CANCER IMMUNOLOGY RESEARCH (2014)
Targeting Fibroblast Activation Protein in Tumor Stroma with Chimeric Antigen Receptor T Cells Can Inhibit Tumor Growth and Augment Host Immunity without Severe Toxicity
Liang-Chuan S. Wang et al.
CANCER IMMUNOLOGY RESEARCH (2014)
Chimeric antigen receptor T cells are vulnerable to immunosuppressive mechanisms present within the tumor microenvironment
Gregory L. Beatty et al.
ONCOIMMUNOLOGY (2014)
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis
Nicole Beauchemin et al.
CANCER AND METASTASIS REVIEWS (2013)
The Weal and Woe of Costimulation in the Adoptive Therapy of Cancer with Chimeric Antigen Receptor (CAR)-Redirected T Cells
A. Hombach et al.
CURRENT MOLECULAR MEDICINE (2013)
Clinical trials in cellular immunotherapy for brain/CNS tumors
Jetan Badhiwala et al.
EXPERT REVIEW OF NEUROTHERAPEUTICS (2013)
Retargeting NK-92 for anti-melanoma activity by a TCR-like single-domain antibody
Ge Zhang et al.
IMMUNOLOGY AND CELL BIOLOGY (2013)
Genetically engineered T cells for the treatment of cancer
M. Essand et al.
JOURNAL OF INTERNAL MEDICINE (2013)
Decreased functional T lymphocyte-mediated cytokine responses in patients with chemotherapy-induced neutropenia
L. Ohrmalm et al.
JOURNAL OF INTERNAL MEDICINE (2013)
Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells
Petra C. Schuberth et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2013)
Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity
Cor H. J. Lamers et al.
MOLECULAR THERAPY (2013)
Genome engineering using the CRISPR-Cas9 system
F. Ann Ran et al.
NATURE PROTOCOLS (2013)
Combining a CD20 Chimeric Antigen Receptor and an Inducible Caspase 9 Suicide Switch to Improve the Efficacy and Safety of T Cell Adoptive Immunotherapy for Lymphoma
Lihua E. Budde et al.
PLOS ONE (2013)
B7-H3 is a new cancer-specific endothelial marker in clear cell renal cell carcinoma
Xiaojian Qin et al.
ONCOTARGETS AND THERAPY (2013)
The Basic Principles of Chimeric Antigen Receptor Design
Michel Sadelain et al.
CANCER DISCOVERY (2013)
T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans
Marcela V. Maus et al.
CANCER IMMUNOLOGY RESEARCH (2013)
Design of a Phase I Clinical Trial to Evaluate Intratumoral Delivery of ErbB-Targeted Chimeric Antigen Receptor T-Cells in Locally Advanced or Recurrent Head and Neck Cancer
May C. I. van Schalkwyk et al.
HUMAN GENE THERAPY CLINICAL DEVELOPMENT (2013)
Truncated Cell-Surface CD19 As a Conditional Suicide Switch For Adoptive T Cell Immunotherapy
Lihua Elizabeth Budde et al.
BLOOD (2013)
Immune reconstitution and strategies for rebuilding the immune system after haploidentical stem cell transplantation
Lena Oevermann et al.
HEMATOPOIETIC STEM CELLS VIII (2012)
Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
Hollie J. Pegram et al.
BLOOD (2012)
Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1)
Ulf Petrausch et al.
BMC CANCER (2012)
CD27 Signaling Increases the Frequency of Regulatory T Cells and Promotes Tumor Growth
Christina Claus et al.
CANCER RESEARCH (2012)
The Future Is Now: Chimeric Antigen Receptors as New Targeted Therapies for Childhood Cancer
Daniel W. Lee et al.
CLINICAL CANCER RESEARCH (2012)
Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma
Richard A. Morgan et al.
HUMAN GENE THERAPY (2012)
CD70 expression patterns in renal cell carcinoma
Lucia B. Jilaveanu et al.
HUMAN PATHOLOGY (2012)
An NKp30-Based Chimeric Antigen Receptor Promotes T Cell Effector Functions and Antitumor Efficacy In Vivo
Tong Zhang et al.
JOURNAL OF IMMUNOLOGY (2012)
Phenotypic and Functional Attributes of Lentivirus-modified CD19-specific Human CD8+ Central Memory T Cells Manufactured at Clinical Scale
Xiuli Wang et al.
JOURNAL OF IMMUNOTHERAPY (2012)
Flexible Targeting of ErbB Dimers That Drive Tumorigenesis by Using Genetically Engineered T Cells
David M. Davies et al.
MOLECULAR MEDICINE (2012)
Correction: Exogenous Amino Acids Are Essential for Interleukin-7 Induced CD8 T Cell Gowth
Claire Pearson et al.
PLoS One (2012)
Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells
Cor H. J. Lamers et al.
BLOOD (2011)
Engraftment of human central memory-derived effector CD8+ T cells in immunodeficient mice
Xiuli Wang et al.
BLOOD (2011)
A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells
Xiuli Wang et al.
BLOOD (2011)
Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
Chrystal U. Louis et al.
BLOOD (2011)
Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
Renier J. Brentjens et al.
BLOOD (2011)
IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression
Markus Chmielewski et al.
CANCER RESEARCH (2011)
EVALUATION OF B7-H3 EXPRESSION AS A BIOMARKER OF BIOCHEMICAL RECURRENCE AFTER SALVAGE RADIATION THERAPY FOR RECURRENT PROSTATE CANCER
Alexander S. Parker et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2011)
Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients
Lukas Baitsch et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy
Antonio Di Stasi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
The effects of adding zoledronic acid to neoadjuvant chemotherapy on tumour response: exploratory evidence for direct anti-tumour activity in breast cancer
R. E. Coleman et al.
BRITISH JOURNAL OF CANCER (2010)
B7-H3 and Its Role in Antitumor Immunity
Martin Loos et al.
CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2010)
Selective Expansion of Chimeric Antigen Receptor-targeted T-cells with Potent Effector Function using Interleukin-4
Scott Wilkie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas
Xingxing Zang et al.
MODERN PATHOLOGY (2010)
Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2
Richard A. Morgan et al.
MOLECULAR THERAPY (2010)
An Enigmatic Tail of CD28 Signaling
Jonathan S. Boomer et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer
Martin Loos et al.
BMC CANCER (2009)
Clinical importance of B7-H3 expression in human pancreatic cancer
I. Yamato et al.
BRITISH JOURNAL OF CANCER (2009)
Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis
Kui Li et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2009)
Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4(+) and CD8(+) T cells for use in the adoptive immunotherapy of cancer
K. Birkholz et al.
GENE THERAPY (2009)
NKG2D and its ligands
Peyman Obeidy et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)
Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo
Michael C. Milone et al.
MOLECULAR THERAPY (2009)
Noninvasive detection of therapeutic cytolytic T cells with F-18-FHBG PET in a patient with glioma
Shahriar S. Yaghoubi et al.
NATURE CLINICAL PRACTICE ONCOLOGY (2009)
BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources
Chunlei Wu et al.
GENOME BIOLOGY (2009)
Tumor antigen precursor protein profiles of adult and pediatric brain tumors identify potential targets for immunotherapy
Jian Gang Zhang et al.
JOURNAL OF NEURO-ONCOLOGY (2008)
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
Martin A. Pule et al.
NATURE MEDICINE (2008)
NK cells and cancer immunosurveillance
I. Waldhauer et al.
ONCOGENE (2008)
The contrasting role of B7-H3
Kimberly A. Hofmeyer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome
Xingxing Zang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling
K. Shtiegman et al.
ONCOGENE (2007)
B7-H3 ligand expression by prostate cancer: A novel marker of prognosis and potential target for therapy
Timothy J. Roth et al.
CANCER RESEARCH (2007)
Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma
Julie R. Park et al.
MOLECULAR THERAPY (2007)
The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignancies
Catia Traversari et al.
BLOOD (2007)
A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer
Michael H. Kershaw et al.
CLINICAL CANCER RESEARCH (2006)
Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates
CL Law et al.
CANCER RESEARCH (2006)
NKG2D in NK and T cell-mediated immunity
K Ogasawara et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2005)
Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
L Gattinoni et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2005)
Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics
SK Bromley et al.
NATURE IMMUNOLOGY (2005)
Identification of CD70 as a diagnostic biomarker for clear cell renal cell carcinoma by gene expression profiling, real-time RT-PCR and immunohistochemistry
J Diegmann et al.
EUROPEAN JOURNAL OF CANCER (2005)
Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
ME Dudley et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
Anti-prostate specific membrane antigen designer T cells for prostate cancer therapy
QZ Ma et al.
PROSTATE (2004)
Identification of 41g-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis
R Castriconi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
4-1 BB enhances CD8+ T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1
HW Lee et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2003)
Human T cell receptor γδ cells recognize endogenous mevalonate metabolites in tumor cells
HJ Gober et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
PM Siegel et al.
NATURE REVIEWS CANCER (2003)
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
K Reif et al.
NATURE (2002)
Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells
L Gorelik et al.
NATURE MEDICINE (2001)
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.
DJ Slamon et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
B7-H3:: A costimulatory molecule for T cell activation and IFN-γ production
AI Chapoval et al.
NATURE IMMUNOLOGY (2001)
Role of TNF receptor-associated factor 2 and p38 mitogen-activated protein kinase activation during 4-1BB-dependent immune response
JL Cannons et al.
JOURNAL OF IMMUNOLOGY (2000)
The leukotriene C4 transporter MRP1 regulates CCL19 (MIP-3β, ELC)-dependent mobilization of dendritic cells to lymph nodes
DF Robbiani et al.
CELL (2000)
分享论文
