期刊
JOURNAL OF CLINICAL MEDICINE
卷 9, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/jcm9092774
关键词
translational medicine; scaffolds; tissue engineering
资金
- POR CALABRIA FESR-FSE 2014-2020-ASSEI-PROMOZIONE DELLA RICERCA E DELL'INNOVAZIONE: Progetto DEMOCEDE-CUP [J18C17000620006]
Translational medicine aims to translate the most promising preclinical research into clinical practice. Oncology is a continuously growing medical field: the scientific research on cancer biology is currently based on in vitro experiments, carried out on tissue culture plates (TCPs) and other 2D samples. In this context, 3D printing has greatly improved the biofabrication of new biological matrices that mimic the extracellular environments, which may characterize healthy from cancerous tissues. Organoids have recently been described in several reports on scientific literature. The term that better describes such organoids-based tumoral tissues is tumoroids. Tumoroids are substantially tumor-like organoids, typically deriving from primary tumors harvested from patients. This topical review aims to give an update on organoids applied in translational medicine, paying specific attention to their use in the investigation of the main molecular mechanisms of cancer onset and growth, and on the most impacting strategies for effective targeted therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据