期刊
NATURE MICROBIOLOGY
卷 5, 期 12, 页码 1459-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41564-020-00793-9
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资金
- C1 Gas Refinery Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2016M3D3A1A01913250]
We engineeredEscherichia colito grow on CO(2)and formic acid alone by introducing the synthetic CO(2)and formic acid assimilation pathway, expressing two formate dehydrogenase genes, fine-tuning metabolic fluxes and optimizing the levels of cytochromebo(3)andbd-I ubiquinol oxidase. Our engineered strain can grow to an optical density at 600 nm of 7.38 in 450 h, and shows promise as a platform strain growing on CO(2)and formic acid alone. Growth ofEscherichia colion carbon dioxide and formate is achieved by rational metabolic engineering alone.
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