期刊
CHEMISTRYSELECT
卷 5, 期 34, 页码 10549-10555出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202002350
关键词
apoptosis; caspase-3; cytotoxicity; dinuclear palladium(II) complexes; 1; 5-naphthyridine
资金
- Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-68/2020-14/200122, 175069, 175071]
- Faculty of Medical Sciences, University of Kragujevac [MP02/19, JP15/19, JP11/18, JP02/20]
- Serbian Academy of Sciences and Arts [01-2019-F65, F128]
- bilateral project with PR China [06/2018]
Five new dinuclear palladium(II) complexes with general formula, [{Pt(L)Cl}(2)(mu-1,5-nphe)](NO3)(2)(L is ethylenediamine (en), (+/-)-1,2-propylenediamine (1,2-pn),trans-(+/-)-1,2-diaminocyclohexane (dach), 1,3-propylenediamine (1,3-pd), (+/-)-1,3-pentanediamine (1,3-pnd) and 1,5-nphe is bridging 1,5-naphthyridine ligand) were synthesised and spectroscopically characterized.In vitrocytotoxic activity of these complexes was evaluated against mouse mammary carcinoma (4T1), colon (CT26), lung cancer cells (LLC1) and melanoma (B16-F10) as well as human lung adenocarcinoma (A549), mammary carcinoma (MDA-MB-468), and colon cancer (HCT 116). The investigated complexes reduced viability of tumor cells in dose dependent manner. Dinuclear Pd(II) complexes act less cytotoxic toward tumor cells, compare to cisplatin, but also have greater selectivity toward mesenchymal stem cells. The potential mechanism of cell death of tumor cells treated with palladium(II) 1,5-naphthyridine dinuclear complexes is enhanced apoptosis, facilitated by down-regulation of anti-apoptotic Bcl-2 and up-regulation of pro-apoptotic Caspase-3.
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