期刊
CHEMISTRYSELECT
卷 5, 期 34, 页码 10511-10515出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202003234
关键词
Hydrogen donor; Nitroarenes; Nitrogen heterocycles; Organocatalysis; Reduction
资金
- MIUR (Rome-Italy)
The transition metal free reduction of aromatic/heteroaromatic nitro compounds to amines has been improved employing phenyl(2-quinolyl)methanol (PQM) as organocatalyst in the presence of NaBH(4)or NaCNBH(3)as stoichiometric reducing agent. The procedure is chemoselective for NO(2)group reduction with high tolerance of many functionalities. The reaction pathway strongly depends on the substituents present on the nitroarene ring. However, a careful choice of the reaction conditions allows to address the reduction process towards the corresponding anilines (isolated in 17-91 % yields). The use of substoichiometric amounts of PQM allows more sustainable processes: reaction products are easily isolated and PQM can be directly recovered at the end of the reaction and recycled.
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