Navigating the Synthesis of Quinoline Hybrid Molecules as Promising Anticancer Agents

The emergence of drug resistance and low specificity with side effects are the significant challenges in pharmaceutical sectors for control of cancer nowadays. Notwithstanding, this is an imperative prerequisite to develop novel anticancer agents through mainstream medicinal chemistry approaches. The intriguing quinoline and its derivatives have demonstrated as significant building blocks for the locating of new promising anticancer agents. Consequently, quinoline moiety with the addition of suitable congeners would offer a strategy for the development of potential drug candidates. This present review article summarizes the recent advances (2018-2020) of quinoline hybrids and their anticancer activity. The mechanism action and plausible structure-activity relationship have discussed.