4.6 Review

Engineering Biomaterials to Guide Heart Cells for Matured Cardiac Tissue

期刊

COATINGS
卷 10, 期 10, 页码 -

出版社

MDPI
DOI: 10.3390/coatings10100925

关键词

extracellular matrix (ECM); biomaterials; cardiac tissue engineering; tissue regeneration; cardiomyocytes; cardiac spheroids; 2D pattern; 3D printing; surface coating; cardiac scaffolds; maturation

资金

  1. National Research Foundation of Korea, Republic of Korea [2016-M3A9B6947892]
  2. Korea University Grant

向作者/读者索取更多资源

The extracellular matrix (ECM) is needed to maintain the structural integrity of tissues and to mediate cellular dynamics. Its main components are fibrous proteins and glycosaminoglycans, which provide a suitable environment for biological functions. Thus, biomaterials with ECM-like properties have been extensively developed by modulating their key components and properties. In the field of cardiac tissue engineering, the use of biomaterials offers several advantages in that biophysical and biochemical cues can be designed to mediate cardiac cells, which is critical for maturation and regeneration. This suggests that understanding biomaterials and their use in vivo and in vitro is beneficial in terms of advancing cardiac engineering. The current review provides an overview of both natural and synthetic biomaterials and their use in cardiac engineering. In addition, we focus on different strategies to recapitulate the cardiac tissue in 2D and 3D approaches, which is an important step for the maturation of cardiac tissues toward regeneration of the adult heart.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据