期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 17, 期 3, 页码 271-274出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201017666151223123424
关键词
Marine fungus; Aspergillus insulicola; sponge; sesquiterpene; lung cancer; cytotoxic activity
资金
- High-Tech Research and Development Program of China [2013AA092901, 2011AA090702]
- National Natural Science Foundation of China [41130858]
- State Key Laboratory of Microbial Metabolism (Shanghai Jiao Tong University) [MMLKF12-07]
The emergence of drug resistance and spread of new infectious diseases necessitated the development of novel antibiotics. Marine sponge-associated fungi represent a reservoir of novel molecules with diverse biological potentials. In this study, we isolated five nitrobenzoyloxy-substituted sesquiterpenes 1-5 from the culture mycelia of an endozoic fungus Aspergillus insulicola MD10-2, obtained from the South China Sea sponge Cinachyrella australiensis. Compound 2 showed cytotoxicity against human lung cancer cell line H-460 with an IC50 value of 6.9 mu M. Cytotoxicity of the acetylated derivatives ( 2a and 2b) of compound 2 decreased markedly, suggesting that the hydroxyl group contributed to the cytotoxic activity. Compound 5 was inactive against H-460, which implied the double bond at C-7 had an effect on cytotoxic activity as well.
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