期刊
FRONTIERS IN GENETICS
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2020.562316
关键词
depression; gender difference; genetics; gene-environment interactions; heritability
资金
- National Natural Science Foundation of China (NSFC) [81871070, 81971276]
- National Key R&D Program of China [2018YFC1311600]
- Jilin Province Medical and Health Talents [2017F012, 2019SCZT007, 2019SCZT013]
- Jilin Science and Technology Agency [20170204049SF, 20190701078GH, 20200201465JC, 20200301005RQ]
- Scientific Research Foundation of the Education Department of Jilin Province [JJKH20201107KJ]
Compared with men, female accounts for a larger proportion of patients with depression. Behavioral genetics researches find gender differences in genetic underpinnings of depression. We found that gender differences exist in heritability and the gene associated with depression after reviewing relevant research. Both genes and gene-environment interactions contribute to the risk of depression in a gender-specific manner. We detailed the relationships between serotonin transporter gene-linked promoter region (5-HTTLPR) and depression. However, the results of these studies are very different. We explored the reasons for the contradictory conclusions and provided some suggestions for future research on the gender differences in genetic underpinnings of depression.
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