期刊
NATIONAL SCIENCE REVIEW
卷 8, 期 6, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/nsr/nwaa198
关键词
aggregation-induced emission; amphiphilic AIEgens; endoplasmic reticulum; targeting specificity; high-fidelity tracking
资金
- National Natural Science Foundation of China (NSFC) Science Center Program [21788102]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX03]
- NSFC Major Research Project [91959202]
- National Key Research and Development Program [2016YFA0200300]
- NSFC/China [21974047, 21622602]
- Shanghai Pujiang Program [19PJ1402300]
- China Postdoctoral Science Foundation [2020M671328]
- Fundamental Research Funds for the Central Universities [222201814013]
- Postdoctoral Science Foundation of Jiangsu Province [2020Z189]
By introducing sulfonate and p-toluenesulfonamide groups, researchers have successfully designed an amphiphilic AIEgen sensor that solves the issue of selective targeting in both hydrophilic and lipophilic biological systems, while also effectively controlling the 'always-on' fluorescence problem.
The current aggregation-induced emission luminogens (AIEgens) sometimes suffer from poor targeting selectivity due to undesirable aggregation in the hydrophilic biosystem with 'always-on' fluorescence or unspecific aggregation in the lipophilic organelle with prematurely activated fluorescence. Herein, we report an unprecedented 'amphiphilic AIEgen' sensor QM-SO3-ER based on the AIE building block of quinoline-malononitrile (QM). The introduced hydrophilic sulfonate group can well control the specific solubility in a hydrophilic system with desirable initial 'fluorescence-off' state. Moreover, the incorporated p-toluenesulfonamide group plays two roles: enhancing the lipophilic dispersity, and behaving as binding receptor to the adenosine triphosphate (ATP)-sensitive potassium (K-ATP) on the endoplasmic reticulum (ER) membrane to generate the docking assay confinement effect with targetable AIE signal. The amphiphilic AIEgen has for the first time settled down the predicament of unexpected 'always-on' fluorescence in the aqueous system and the untargetable aggregation signal in the lipophilic organelle before binding to ER, thus successfully overcoming the bottleneck of AIEgens' targetability.
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