期刊
CURRENT ORGANIC CHEMISTRY
卷 21, 期 1, 页码 53-63出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272820666160510171040
关键词
Chronic wound; bioactive wound dressing; bioactive compounds; antibiotic resistance
资金
- [PN-II-RU-TE-2014-4-2037]
- [PN-III-P2-2.1-BG-2016-0369]
This article offers a review regarding current approaches in bioactive dressings design, the bioactive components as well as the experimental models used to assess their efficiency. Wound dressings come in a variety of materials including natural polymers and synthetic polymers manufactured into various forms, such as foams, films, hydrocolloids, hydrogels, sponges, membranes, skin substitutes, electrospun micro and nanofibers. Until now there is no available dressing able to meet the criteria for a fast and adequate wound healing. The dressing material may have intrinsic wound healing activity or/and may serve as a support for the release of bioactive compounds such as antimicrobial agents (antibiotics, antiseptics, honey, plant extracts), growth factors, insulin. There are a lot of controversies regarding the use of antimicrobials in the wounds management. However non -antibiotic antibacterial treatment regiments are a must due to alarming antibiotic resistance. Most of the developed bioactive wound dressings were not tested on human patients, and may prove not applicable in clinical settings. Therefore, appropriately designed clinical studies are necessary to establish the safety profile and the efficacy of novel bioactive dressings, in terms of ease of use, cost-effectiveness and patient satisfaction, combined with in depth fundamental research of the mechanisms of action of different dressing's components.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据