期刊
INFLAMMOPHARMACOLOGY
卷 28, 期 6, 页码 1439-1455出版社
SPRINGER BASEL AG
DOI: 10.1007/s10787-020-00751-1
关键词
Alkaloids; Marine natural products; Polyphenols; NF-kappa B; Terpenes
Alzheimer's disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD.
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