期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 41, 期 -, 页码 109-118出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2016.06.015
关键词
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资金
- UK Biotechnology and Biological Sciences Research Council (BBSRC) [BB/I020411/1]
- Biotechnology and Biological Sciences Research Council [BB/I020411/1] Funding Source: researchfish
- BBSRC [BB/I020411/1] Funding Source: UKRI
Molecular oxygen (O-2), in spite being a potentially strong oxidant, typically displays very poor reactivity with organic molecules. This is largely due to quantum chemical reasons as O-2 in its ground state is a diradical (O-3(2)) whilst common organic substrates are in a singlet state. For this reason catalysis involving O-2 as a reactant is typically mediated by enzymes containing redox metal and/or organic co-factors. Cofactor independent oxygenases (and oxidases) are therefore intriguing enzymes from a fundamental viewpoint. This review looks at recent advances that have been made in understanding of this class of intriguing biocatalysts highlighting the power of an inter-disciplinary approach involving structural biology, spectroscopy and theoretical methods.
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