期刊
FRONTIERS IN IMMUNOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.588682
关键词
glucocorticoid-induced TNFR-related protein; GITRL; T cell; myeloid cells; autoimmune diseases
类别
资金
- National Natural Science Foundation of China [81971542, 81701612]
- Natural Science Foundation of Jiangsu [BK20170563]
- Summit of the Six Top Talents Program of Jiangsu Province [2017-YY-006]
- Jiangsu Province's Key Medical Talents Program [ZDRCB2016018]
Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily which is expressed in various cells, including T cells, natural killer cells and some myeloid cells. GITR is activated by its ligand, GITRL, mainly expressed on antigen presenting cells and endothelial cells. It has been acknowledged that the engagement of GITR can modulate both innate and adaptive immune responses. Accumulated evidence suggests GITR/GITRL interaction is involved in the pathogenesis of tumor, inflammation and autoimmune diseases. In this review, we describe the effects of GITR/GITRL activation on effector T cells, regulatory T cells (Tregs) and myeloid cells; summarize its role and the underlying mechanisms in modulating autoimmune diseases.
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