期刊
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
卷 20, 期 4, 页码 171-179出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cossms.2016.04.001
关键词
Mechanotransduction; Substrate stiffness; 3D culture; Tissue engineering; Stem cell differentiation
资金
- NIH [R21 EB018407-01, U19 AI116484-01, R21 EB020235-01]
- NSF DMR [1508006]
- California Institute for Regenerative Medicine [RT3-07948]
- Stanford University [SICB-112878]
- Irish Research Council ELEVATE fellowship [ELEVA-TEPD/2013/30]
- Bio-X [IIP-7-75]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1508006] Funding Source: National Science Foundation
The role of substrate mechanics in guiding mesenchymal stem cell (MSC) fate has been the focus of much research over the last decade. More recently, the complex interplay between substrate mechanics and other material properties such as ligand chemistry and substrate degradability to regulate MSC differentiation has begun to be elucidated. Additionally, there are several changes in the presentation of these material properties as the dimensionality is altered from two- to three-dimensional substrates, which may fundamentally alter our understanding of substrate-induced mechanotransduction processes. In this review, an overview of recent findings that highlight the material properties that are important in guiding MSC fate decisions is presented, with a focus on underlining gaps in our existing knowledge and proposing potential directions for future research. (C) 2016 Elsevier Ltd. All rights reserved.
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