期刊
BMC MEDICINE
卷 13, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12916-015-0297-4
关键词
Alzheimer's disease; Beta-amyloid; Clinical trials
资金
- AC Immune SA
- Accera Inc
- Baxter
- Bristol-Myers Squibb
- Elan
- Eli Lilly
- Genentech Inc.
- Hoffman La Roche Inc.
- Janssen Pharmaceuticals
- Merck
- NATIONAL INSTITUTE ON AGING [U19AG010483] Funding Source: NIH RePORTER
Alzheimer's disease (AD) is the foremost cause of dementia worldwide. Clinically, AD manifests as progressive memory impairment followed by a gradual decline in other cognitive abilities leading to complete functional dependency. Recent biomarker studies indicate that AD is characterized by a long asymptomatic phase, with the development of pathology occurring at least a decade prior to the onset of any symptoms. Current FDA-approved treatments target neurotransmitter abnormalities associated with the disease but do not affect what is believed to be the underlying etiology. In this review, we briefly discuss the most recent therapeutic strategies being employed in AD clinical trials, as well the scientific rationale with which they have been developed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据