期刊
FRONTIERS IN IMMUNOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.573920
关键词
head and neck squamous cell carcinoma (HNSCC); gamma delta T cells; butyrophilin; MICB; TCGA; ImmuCellAI; CIBERSORTx
类别
资金
- National Natural Science Foundations of China [81972532, 81772896, 81630025]
- Science and Technology Planning Project of Guangzhou City of China [2017004020102]
gamma delta T cells are a small subset of unconventional T cells that are enriched in the mucosal areas, and are responsible for pathogen clearance and maintaining integrity. However, the role of gamma delta T cells in head and neck squamous cell carcinoma (HNSCC) is largely unknown. Here, by using RNA-seq data from The Cancer Genome Atlas (TCGA), we discovered that HNSCC patients with higher levels of gamma delta T cells were positively associated with lower clinical stages and better overall survival, and high abundance of gamma delta T cells was positively correlated with CD8+/CD4+ T cell infiltration. Gene ontology and pathway analyses showed that genes associated with T cell activation, proliferation, effector functions, cytotoxicity, and chemokine production were enriched in the group with a higher gamma delta T cell abundance. Furthermore, we found that the abundance of gamma delta T cells was positively associated with the expression of the butyrophilin (BTN) family proteins BTN3A1/BTN3A2/BTN3A3 and BTN2A1, but only MICB, one of the ligands of NKG2D, was involved in the activation of gamma delta T cells, indicating that the BTN family proteins might be involved in the activation and proliferation of gamma delta T cells in the tumor microenvironment of HNSCC. Our results indicated that gamma delta T cells, along with their ligands, are promising targets in HNSCC with great prognostic values and treatment potentials.
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