期刊
FRONTIERS IN IMMUNOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.580208
关键词
polyphenol; gallic acid; gut microbiome; immune response; gastrointestinal health
类别
资金
- National Key R&D Program of China [2018YFD0500600]
- National Natural Science Foundation of China [31790411]
- Natural Science Foundation of Guangdong Province [2020A1515010322]
- Innovation Team Project in Universities of Guangdong Province [2017KCXTD002]
- Guangdong Basic and Applied Basic Research Foundation [2019B1515210002]
- Guangdong Provincial Promotion Project on Preservation and Utilization of Local Breed of Livestock and Poultry
Gallic acid (GA) is a naturally occurring polyphenol compound present in fruits, vegetables, and herbal medicines. According to previous studies, GA has many biological properties, including antioxidant, anticancer, anti-inflammatory, and antimicrobial properties. GA and its derivatives have multiple industrial uses, such as food supplements or additives. Additionally, recent studies have shown that GA and its derivatives not only enhance gut microbiome (GM) activities, but also modulate immune responses. Thus, GA has great potential to facilitate natural defense against microbial infections and modulate the immune response. However, the exact mechanisms of GA acts on the GM and immune system remain unclear. In this review, first the physicochemical properties, bioavailability, absorption, and metabolism of GA are introduced, and then we summarize recent findings concerning its roles in gastrointestinal health. Furthermore, the present review attempts to explain how GA influences the GM and modulates the immune response to maintain intestinal health.
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