期刊
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
卷 11, 期 3, 页码 1199-1217出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13346-020-00848-8
关键词
Microneedles; HIV; Opinions; Healthcare professional; Lay public; Patient
资金
- Department for the Economy Northern Ireland (DFENI) [EP/S028919/1]
- Engineering and Physical Sciences Research Council (EPSRC) [EP/S028919/1]
This study aimed to investigate the perspectives of various end-users regarding the translation of MN technology to clinical practice, particularly in the delivery of antiretroviral therapy for HIV. Through quantitative surveys and qualitative focus group discussions, it was found that there was positive feedback on the use of MN technology for HIV treatment, highlighting its potential benefits and user concerns.
Poor adherence to oral antiretroviral therapy (ART) remains an important challenge in the treatment of HIV. Microneedles (MN) potentially could offer a non-invasive long-acting (LA) delivery approach, avoiding the need for daily dosing of ART. However, this claim has yet to be explored amongst its potential end-users. The aim of this mixed methods study was to investigate the perspectives from various end-users surrounding the translation of MN technology to general clinical practice, with a particular focus on delivery of ART. Quantitative postal questionnaires were distributed amongst healthcare professionals (HCPs) and the lay public (LP). A total of 208 responses were obtained (HCP, 69; LP, 139), with a completion rate of 34.7%. The consensus on MN technology was positive from both demographics (HCP, 97.1%; LP, 98.6%), with further strong support of postulated MN use within HIV (HCP, 97.1%; LP, 98.6%). Qualitative focus groups were employed to investigate in-depth, the perspectives of 12 patients with HIV. Again, consensus on MN technology was positive, highlighting benefits pertinent to HIV, including discreet self-application and potential sustained release thus avoiding daily oral ART and associated side effects. Patient concerns focused on the need for varied MN dosing schedules and a reluctance to change from established ART. The findings of this study provide an initial indication of MN acceptability, particularly for use within HIV, from various end-user demographics. Furthermore, concerns raised advocate the importance of continued translational research in this area and should act as motivators for those in MN development to ensure a patient-centred MN product is delivered.
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