期刊
CURRENT OPINION IN INSECT SCIENCE
卷 43, 期 -, 页码 29-38出版社
ELSEVIER
DOI: 10.1016/j.cois.2020.10.002
关键词
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资金
- Spanish MINECO [PGC2018-098427-B-I00]
- Catalan Government [2017 SGR01030]
Proper formation of adult insects requires the integration of spatial and temporal regulatory axes. Temporal specificity is achieved through interactions between temporal identity genes controlled by developmental hormones. The Metamorphic Gene Network (MGN) comprises genes like Kr-h1, E93, and Br-C to specify life stage identity.
Proper formation of adult insects requires the integration of spatial and temporal regulatory axes. Whereas spatial information confers identity to each tissue, organ and appendage, temporal information specifies at which stage of development the animal is. Regardless of the type of post embryonic development, either hemimetabolous or holometabolous, temporal specificity is achieved through interactions between the temporal identity genes Kr-h1, E93 and Br-C, whose sequential expression is controlled by the two major developmental hormones, 20-hydroxyecdysone and Juvenile hormone. Given the intimate regulatory connection between these three factors to specify life stage identity, we dubbed the regulatory axis that comprises these genes as the Metamorphic Gene Network (MGN). In this review, we survey the molecular mechanisms underlying the control by the MGN of stage identity and progression in hemimetabolous and holometabolous insects.
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