Integration of calcium and ABA signaling

Abiotic stresses simultaneously trigger an increase in the level of the plant hormone abscisic acid (ABA) and in the concentration of cytosolic calcium. Subsequent signaling cascades convey stomata regulation and transcriptional responses. Increasing evidence points to direct interrelations of both signaling systems on multiple levels of information processing. In this context, protein phosphatases 2Cs of the Glade A appear to function as master regulators of both ABA and calcium signaling. In this review, we focus on informative examples for convergence of ABA and calcium signaling on common target proteins and discuss emerging concepts, consequences and open questions about the integration of calcium and ABA signaling.