期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 6, 期 10, 页码 5377-5398出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.0c00713
关键词
mucus; mucins; omics; functional materials; bioinspired materials; biomimetics
资金
- CUNY Science Scholarship
- CUNY Llewellyn Fellowship
- National Science Foundation [IOS 1050596, IOS 1656753]
- German Research Foundation [DFG: MA 4147/7-1, MA 4147/7-2]
- Vicerrectoria de Investigacion, Universidad Estatal a Distancia, Costa Rica
- Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-2016-04967, RGPAS-2016-493149, RGPIN-2018-05243]
- National Science Foundation NSF [IOS 1755397]
- Camille & Henry Dreyfus Foundation
- National Institutes of Health (NIH-NIMHD) [8-G-12-MD007599]
- US National Science Foundation [NSF OCE 1442206, OCE 1642311]
- El Laboratorio de Ecologia Urbana de Costa Rica
- CUNY Graduate Center Graduate Fellowship program
- Norwegian Research Council [17541/S10-FUGE, 133335/V40]
- Air Force Office of Scientific Research [FA9550-17-0189, FA9550-19-1-0220]
- DFG (Deutsche Forschungsgemeinschaft)
- Royal Society of London
The functions of secreted animal mucuses are remarkably diverse and include lubricants, wet adhesives, protective barriers, and mineralizing agents. Although present in all animals, many open questions related to the hierarchical architectures, material properties, and genetics of mucus remain. Here, we summarize what is known about secreted mucus structure, describe the work of research groups throughout the world who are investigating various animal mucuses, and relate how these studies are revealing new mucus properties and the relationships between mucus hierarchical structure and hydrogel function. Finally, we call for a more systematic approach to studying animal mucuses so that data sets can be compared, omics-style, to address unanswered questions in the emerging field of mucomics. One major result that we anticipate from these efforts is design rules for creating new materials that are inspired by the structures and functions of animal mucuses.
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