期刊
FRONTIERS IN PHYSIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2020.575181
关键词
left ventricular remodeling; epicardial adipose tissue; inflammation; cytokines; biomarkers; echocardiography
类别
资金
- University of Naples Federico II
- Compagnia di San Paolo e l'Istituto Banco di Napoli within the competitive grant STAR 2018
- COEPICA FESR-Regione Campania
Introduction Left ventricular (LV) remodeling after ST-segment elevation myocardial infarction (STEMI) is explained only in part by the infarct size, and the inter-patient variability may be ascribed to different inflammatory response to myocardial injury. Epicardial adipose tissue (EAT) is a source of inflammatory mediators which directly modulates the myocardium. EAT increase is associated to several cardiovascular diseases; however, its response to myocardial injury is currently unknown. Among inflammatory mediators, IL-13 seems to play protective role in LV regeneration, but its variations after STEMI have not been described yet. Purpose: In the present study we analyzed the association between infarct-related changes of EAT and IL-13 in post-STEMI LV remodeling. Methods We enrolled 100 patients with STEMI undergoing primary angioplasty. At the enrolment (T0) and after 3 months (T1), we measured EAT thickness by echocardiography and circulating levels of IL-13 by ELISA. Results At T1, the 60% of patients displayed increased EAT thickness (Delta EAT > 0). Delta EAT was directly associated to LV end-diastolic volume (r = 0.42; p = 0.014), LV end-systolic volume (r = 0.42; p = 0.013) and worse LV ejection fraction (LVEF) at T1 (r = -0.44; p = 0.0094), independently of the infarct size. In the overall population IL-13 levels significantly decreased at T1 (p = 0.0002). The Delta IL-13 was directly associated to Delta LVEF (r = 0.42; p = 0.017) and inversely related to Delta EAT (r = -0.51; p = 0.022), thus suggesting a protective role for IL-13. Conclusion The variability of STEMI-induced inflammatory response may be associated to the post-infarct LV remodeling. Delta EAT thickness and Delta IL-13 levels could be novel prognostic markers in STEMI patients.
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