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注意:仅列出部分参考文献,下载原文获取全部文献信息。Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice
Yan Liu et al.
EMERGING MICROBES & INFECTIONS (2019)
Characterization and Clinical Significance of Natural Variability in Hepatitis B Virus Reverse Transcriptase in Treatment-Naive Chinese Patients by Sanger Sequencing and Next-Generation Sequencing
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JOURNAL OF CLINICAL MICROBIOLOGY (2019)
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Trends in hepatitis B virus resistance to nucleoside/nucleotide analogues in North China from 2009-2016: A retrospective study
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INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2018)
Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B
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Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China
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MICROBIAL DRUG RESISTANCE (2017)
Substitutions of rtL228 and/or L229 are involved in the regulation of replication and HBsAg secretion in hepatitis B virus, and do not affect susceptibility to nucleos(t)ide analogs
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MOLECULAR MEDICINE REPORTS (2017)
Naturally occurring mutations in the reverse transcriptase region of hepatitis B virus polymerase from treatment- naive Korean patients infected with genotype C2
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WORLD JOURNAL OF GASTROENTEROLOGY (2017)
Genotyping of HBV and tracking of resistance mutations in treatment-naive patients with chronic hepatitis B
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INFECTION AND DRUG RESISTANCE (2017)
Naturally occurring genotypic drug-resistant mutations of HBV in Huzhou, China: a single-center study
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INFECTION AND DRUG RESISTANCE (2017)
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy
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SCIENTIFIC REPORTS (2017)
Overview of hepatitis B viral replication and genetic variability
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JOURNAL OF HEPATOLOGY (2016)
The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013
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LANCET (2016)
Incidence of natural resistance mutations in naive chronic hepatitis B patients: A systematic review and meta-analysis
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JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015)
Characterization of novel entecavir resistance mutations
Sanae Hayashi et al.
JOURNAL OF HEPATOLOGY (2015)
The I-TASSER Suite: protein structure and function prediction
Jianyi Yang et al.
NATURE METHODS (2015)
Nucleotide analogue-resistant mutations in hepatitis B viral genomes found in hepatitis B patients
Jiyun Fan et al.
JOURNAL OF GENERAL VIROLOGY (2015)
Mutations in HBV DNA Polymerase Associated With Nucleos(t)ide Resistance Are Rare in Treatment-naive Patients
Philip Vutien et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2014)
The Impact of the Hepatitis B Virus Polymerase rtA181T Mutation on Replication and Drug Resistance Is Potentially Affected by Overlapping Changes in Surface Gene
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JOURNAL OF VIROLOGY (2014)
A description of the hepatitis B virus genomic background in a high-prevalence area in China
Xiaoming Chen et al.
VIROLOGY JOURNAL (2014)
Hepatitis B virus genotype C encoding resistance mutations that emerge during adefovir dipivoxil therapy: in vitro replication phenotype
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HEPATOLOGY INTERNATIONAL (2013)
Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy
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Antiviral Resistance Mutations and Genotype-Associated Amino Acid Substitutions in Treatment-Naive Hepatitis B Virus-Infected Individuals from the Indian Subcontinent
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INTERVIROLOGY (2012)
The rtL229 substitutions in the reverse transcriptase region of hepatitis B virus (HBV) polymerase are potentially associated with lamivudine resistance as a compensatory mutation
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JOURNAL OF CLINICAL VIROLOGY (2012)
Management of treatment failure in chronic hepatitis B
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JOURNAL OF HEPATOLOGY (2012)
Discrepancy of potential antiviral resistance mutation profiles within the HBV reverse transcriptase between nucleos(t)ide analogue-untreated and -treated patients with chronic hepatitis B in a hospital in China
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JOURNAL OF MEDICAL VIROLOGY (2012)
Dynamics of Hepatitis B Virus Quasispecies in Association with Nucleos(t)ide Analogue Treatment Determined by Ultra-Deep Sequencing
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PLOS ONE (2012)
Evolutionary patterns of hepatitis B virus quasispecies under different selective pressures: correlation with antiviral efficacy
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GUT (2011)
Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern
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Characterization of potential antiviral resistance mutations in hepatitis B virus reverse transcriptase sequences in treatment-naive Chinese patients
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ANTIVIRAL RESEARCH (2010)
Mechanistic Characterization and Molecular Modeling of Hepatitis B Virus Polymerase Resistance to Entecavir
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PLOS ONE (2010)
The profile of mutational clusters associated with lamivudine resistance can be constrained by HBV genotypes
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JOURNAL OF HEPATOLOGY (2009)
S2075 Prevalence of HBV DNA Polymerase (B-DNA Pol) Mutations in 345 Patients with Treatment-NaïVe Chronic Hepatitis B (CHB)
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Comprehensive evaluation of hepatitis B virus reverse transcriptase substitutions associated with entecavir resistance
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JOURNAL OF VIROLOGY (2007)
In vitro study of the effects of precore and lamivudine-resistant mutations on hepatitis B virus replication
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JOURNAL OF VIROLOGY (2007)
In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector
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