4.2 Article

Relapse of Symptomatic Cerebrospinal Fluid HIV Escape

期刊

CURRENT HIV/AIDS REPORTS
卷 17, 期 5, 页码 522-528

出版社

SPRINGER
DOI: 10.1007/s11904-020-00526-x

关键词

HIV; Antiretroviral treatment; Cerebrospinal fluid; Viral escape; Central nervous system; Reservoir

资金

  1. Italian Gilead Sciences Fellowship Program
  2. National Institutes of Health (National Institute of Allergy and Infectious Diseases) [R01NS09406701]

向作者/读者索取更多资源

Purpose of Review Symptomatic cerebrospinal fluid (CSF) HIV escape defines the presence of neurological disease in combination antiretroviral therapy (cART)-treated persons due to HIV replication in CSF despite systemic suppression or to higher viral replication in CSF than in plasma. The aim was to search for cases of recurrent symptomatic CSF escape and to define their characteristics. Recent Findings By review of the literature, we identified symptomatic CSF escape relapses in three patients who had shown clinical remission of a first escape episode following cART optimization. By examination of our cohort of 21 patients with symptomatic CSF escape, we identified five additional patients. In the latter, viral escape relapsed over a median follow-up of 108 months because of low adherence or upon treatment simplification of a previously optimized regimen. cART reoptimization based on resistance profile and potential drug neuropenetration and efficacy led to relapse resolution with no further episodes after a median follow-up of 50 months from relapse. The observation that CSF escape may relapse highlights the importance of long-term neuro-suppressive regimens after a first episode and supports the role of the brain as a reservoir for HIV.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据