期刊
CATALYSTS
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/catal10101209
关键词
Suzuki– Miyaura coupling; palladium; continuous-flow reaction; ligand-free; chelate resin; aromatic chloride
资金
- New Energy and Industrial Technology Development Organization (NEDO) [P19004]
The Suzuki-Miyaura coupling reaction is one of the most widely utilized C-C bond forming methods to create (hetero)biaryl scaffolds. The continuous-flow reaction using heterogeneous catalyst-packed cartridges is a practical and efficient synthetic method to replace batch-type reactions. A continuous-flow ligand-free Suzuki-Miyaura coupling reaction of (hetero)aryl iodides, bromides, and chlorides with (hetero)aryl boronic acids was developed using cartridges packed with spherical resin (tertiary amine-based chelate resin: WA30)-supported palladium catalysts (7% Pd/WA30). The void space in the cartridge caused by the spherical catalyst structures enables the smooth flow of a homogeneously dissolved reaction solution that consists of a mixture of organic and aqueous solvents and is delivered by the use of a single syringe pump. Clogging or serious backpressure was not observed.
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