4.3 Article

Effect of S-allylcysteine against diabetic nephropathy via inhibition of MEK1/2-ERK1/2-RSK2 signalling pathway in streptozotocin-nicotinamide-induced diabetic rats

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ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
卷 129, 期 1, 页码 213-221

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TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2020.1811731

关键词

Diabetic nephropathy; S-allylcysteine; MEK1; 2-ERK1; 2-RSK2 signalling; Natural products

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The study evaluated the ameliorative effect of SAC on diabetic nephropathy and found that SAC can protect the kidney by regulating the MEK1/2-ERK1/2-RSK2 signaling pathway.
Objective In the current study, we evaluated the ameliorative effect of S-allylcysteine (SAC) against streptozotocin (STZ)-nicotinamide (NAD)-induced diabetic nephropathy (DN) in rats and also an attempt was made to establish the molecular mechanism of SAC. Methods DN rats were orally supplemented with SAC (150 mg/kg body weight) for a period of 45 days and the effect of SAC on urinary albumin excretion, metabolic parameters, and tubular injury biomarkers by ELISA, total levels and phosphorylation of MEK1/2, ERK1/2, and RSK2 by western blotting analysis in control and experimental rats were assessed. Results From this study, we observed that SAC considerably decreased polydipsia, poly urea, polyphagia, albuminuria and the levels of urinary N-acetyl-beta-D-glucosaminidase, neutrophil gelatinase-associated lipocalin, transforming growth factor-beta 1 and SAC effectively altered the pathological changes in DN rats. SAC also reserved renal cortical phosphorylation of MEK1/2, ERK1/2 and RSK2. Conclusion Hence this study recommended that SAC can successfully protect the DN through regulation of MEK1/2-ERK1/2-RSK2 signalling.

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