期刊
ADVANCED MATERIALS INTERFACES
卷 7, 期 19, 页码 -出版社
WILEY
DOI: 10.1002/admi.202001060
关键词
amyloid; biomaterials; biomedical applications; biomimetics; organic-inorganic hybrid; self-assembly
资金
- National Natural Science Foundation of China [51673112, 21875132, 51903146]
- 111 Project [B14041]
- Distinguished Young Scholars in Shaanxi Province of China [2018JC018]
- Fundamental Research Funds for the Central Universities [GK201801003, 2017CBY004, GK202007006]
- Innovation Capability Support Program of Shaanxi [2020TD-024]
- Open Project of the State Key Laboratory of Supramolecular Structure and Materials [sklssm2019032]
- General Financial Grant from the China Postdoctoral Science Foundation [2017M623109]
- Natural Science Foundation of Shaanxi Province [2020JQ-420]
Protein assembly with ordered architecture plays an important role in the formation of natural organic-inorganic hybrid materials, and also determines their distinguished mechanical, optical, and biochemical properties. Nevertheless, it has been a huge challenge to synthesize materials with hierarchical structure accurately mimicking the natural hybrid materials in vitro. In the past decade, protein amyloid aggregates, due to their diverse and controllable nanostructures and unique properties, have been developed as superior templates or building blocks to fabricate functional organic-inorganic hybrid materials, and applications of these hybrids especially in the field of biomedicine have been also intensively exploited. In this work, the formation process of protein amyloid aggregates and their final distinctive nanostructures are briefly introduced. The mediation of amyloid aggregates on incorporating inorganic nanomaterials and the resultant 1D, 2D, and 3D organic-inorganic hybrid materials are then summarized. In addition, the biomedical applications of these hybrid materials in drug delivery, biomineralization, bioimaging, and biosensors, and cell culture are exemplified. Finally, the challenges and the future research directions on amyloids-based organic-inorganic hybrid materials are prospected.
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