期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 39, 期 -, 页码 122-132出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2016.05.004
关键词
-
资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB 655]
- European Research Council (ERC) [250197]
- DFG
- Fonds der Chemischen Industrie
Neocortex expansion in development and evolution reflects an increased and prolonged activity of neural progenitor cells. Insight into key aspects of the underlying cell biology has recently been obtained. First, the restriction of apical progenitors to undergo mitosis at the ventricular surface is overcome by generation of basal progenitors, which are free to undergo mitosis at abventricular location, typically the subventricular zone. This process involves basolateral ciliogenesis, delamination from the apical adherens junction belt, and loss of apical cell polarity. Second, proliferative capacity of basal progenitors is supported by self-produced extracellular matrix constituents, which in turn promote growth factor signalling. Humans amplify these processes by characteristic alterations in expression of key regulatory genes (PAX6), and via human-specific genes (ARHGAP11B).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据