期刊
CURRENT OPINION IN MICROBIOLOGY
卷 33, 期 -, 页码 105-112出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2016.07.006
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资金
- Structure et Dynamique des Systemes Vivants doctoral school, Universite Paris Saclay
- Direction Generale de l'Armement (DGA-MRIS Scholarship)
- Biotechnology and Biological Sciences Research Council, Centre for synthetic biology of fine and speciality chemicals [BB/M017702/1]
- GIP Genopole
- Toulouse White Biotech (TWB)
- French National Research Agency [ANR-15-CE1-0008]
- BBSRC [BB/M017702/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M017702/1] Funding Source: researchfish
Bacteria rely on allosteric transcription factors (aTFs) to sense a wide range of chemicals. The variety of effectors has contributed in making aTFs the most used input system in synthetic biological circuits. Considering their enabling role in biotechnology, an important question concerns the size of the chemical space that can potentially be detected by these biosensors. From digging into the ever changing repertoire of natural regulatory circuits, to advances in aTF engineering, we review here different strategies that are pushing the boundaries of this chemical space. We also review natural and synthetic cases of indirect sensing, where aTFs work in combination with metabolism to enable detection of new molecules.
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