期刊
CURRENT OPINION IN MICROBIOLOGY
卷 30, 期 -, 页码 98-106出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2016.01.008
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资金
- Fondation Armand-Frappier
- Natural Sciences and Engineering Research Council Canada (NSERC) [RGPIN 250129-07]
- Centre de Recherche en Infectiologie Porcine et Avicole
- Canada Research Chairs program
- Fonds Quebecois de la Recherche sur la Nature et les Technologies
The ability of bacterial pathogens to colonize specific host niches is largely dependent on acquisition of essential metabolites and co-factors for growth and sensing and adapting in response to specific environmental cues. Nutrient availability in host environments is strongly influenced by host physiology and immunity, diet, and competition with other members of the host microbiota. Rapid adaptation to environmental cues and nutrient availability is a hallmark of bacterial fitness and virulence. This adaptability requires complex regulatory networks that tightly link sensing of nutrient availability to expression of virulence genes accordingly. This review focuses on recent findings highlighting the ability of bacterial pathogens to compete for nutrient acquisition in the host-microbiota environment, and emphasizes key aspects mediating the multi-tiered regulatory cascades that coordinately control nutrient sensing and expression of virulence genes in pathogenic Enterobacteria.
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