期刊
JOURNAL OF NANOBIOTECHNOLOGY
卷 18, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12951-020-00685-4
关键词
Coronavirus; SARS-CoV-2; Nanotechnology; Nanoparticles; Nanosensors; Nano-vaccines
资金
- Sao Paulo Research Foundation (FAPESP) [2017/21004-5, 2017/24402-1, 2019/05100-0, 2018/21142-1, 2018/23608-8, 2020/05816-2]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil [CAPES-COFECUB 88887.363975/2019-00]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/21004-5, 17/24402-1] Funding Source: FAPESP
Incidents of viral outbreaks have increased at an alarming rate over the past decades. The most recent human coronavirus known as COVID-19 (SARS-CoV-2) has already spread around the world and shown R(0)values from 2.2 to 2.68. However, the ratio between mortality and number of infections seems to be lower in this case in comparison to other human coronaviruses (such as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV)). These outbreaks have tested the limits of healthcare systems and have posed serious questions about management using conventional therapies and diagnostic tools. In this regard, the use of nanotechnology offers new opportunities for the development of novel strategies in terms of prevention, diagnosis and treatment of COVID-19 and other viral infections. In this review, we discuss the use of nanotechnology for COVID-19 virus management by the development of nano-based materials, such as disinfectants, personal protective equipment, diagnostic systems and nanocarrier systems, for treatments and vaccine development, as well as the challenges and drawbacks that need addressing.
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