期刊
CURRENT OPINION IN IMMUNOLOGY
卷 38, 期 -, 页码 45-51出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2015.11.003
关键词
-
类别
资金
- Canadian Institutes of Health Research (CIHR)
- Canadian Cancer Society Research Institute (CCSRI)
- Fonds de la recherche du Quebec-Sante (FRQS)
- Bristol Myers-Squibb
The signaling lymphocytic activation molecule (SLAM) family is a group of six receptors restricted to hematopoietic cells. Most of these receptors are self-ligands, and thus are triggered in the context of interactions between hematopoietic cells. By way of their cytoplasmic domain, SLAM-related receptors associate with the SLAM-associated protein (SAP) family of adaptors, which control the signals and functions of SLAM family receptors. Recent findings have provided new insights into the key roles of SLAM family receptors in normal immunity, their involvement in human diseases and their usefulness as drug targets to treat human malignancies. These data are reviewed herein.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据