期刊
FRONTIERS IN PLANT SCIENCE
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpls.2020.541968
关键词
shoot development; Arabidopsis; HAIRY MERISTEM; stem cells; confocal imaging; shoot apical meristems
资金
- Purdue University
- Purdue Center for Plant Biology
- Howard Hughes Medical Institute
InArabidopsisshoot apical meristems (SAMs), a well-characterized regulatory loop between WUSCHEL (WUS) and CLAVATA3 (CLV3) maintains stem cell homeostasis by regulating the balance between cell proliferation and cell differentiation. WUS proteins, translated in deep cell layers, move into the overlaying stem cells to activateCLV3. The secreted peptide CLV3 then regulatesWUSlevels through a ligand-receptor mediated signaling cascade.CLV3is specifically expressed in the stem cells and repressed in the deep cell layers despite presence of the WUS activator, forming an apical-basal polarity along the axis of the SAM. Previously, we proposed and validated a hypothesis that the HAIRY MERISTEM (HAM) family genes regulate this polarity, keeping the expression ofCLV3off in interior cells of the SAM. However, the specific role of each individual member of the HAM family in this process remains to be elucidated. Combining live imaging and molecular genetics, we have dissected the conserved and distinct functions of different HAM family members in control ofCLV3patterning in the SAMs and in thede novoshoot stem cell niches as well.
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