期刊
FRONTIERS IN MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.562063
关键词
Aspergillus violaceofuscus; natural products; biosynthesis; fungal secondary metabolites; polyketide-non-ribosomal peptides
类别
资金
- City University of Hong Kong [7200579, 9610412]
- National Natural Science Foundation of China [21907083]
A new polyketide-non-ribosomal peptide hybrid molecule, pyranoviolin A (1), was discovered from the genome-sequenced fungusAspergillus violaceofuscusCBS 115571 and was characterized to be the first pyranonigrin analog harboring the C-3 methoxy group. Examination of the genome sequence of the fungus identified a putative biosynthetic gene cluster of1, which was designated as thepyvcluster. The gene deletion experiment of the polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) hybrid gene in the cluster confirmed the involvement of thepyvcluster in the pyranoviolin A biosynthesis. Finally, a plausible biosynthetic route leading to1has been proposed based on the bioinformatic analysis. Our study indicates that metabolite analysis of genome-sequenced microorganisms whose metabolites have been largely unexplored facilitates the discovery of new secondary metabolites along with their biosynthetic gene clusters.
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