期刊
FRONTIERS IN MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.01966
关键词
Pseudomonas aeruginosa; Acinetobacter baumannii; carbapenem; colistin; RTI; IAI; UTI
类别
资金
- Merck & Co., Inc., Kenilworth, NJ, United States
- National Key Research and Development Program of China [2018YFC1200100, 2018YFC1200105]
- Chinese Academy of Medical Sciences (CAMS) Initiative for Innovative Medicine [2016-I2M-3-014]
- Outstanding Talents Training Funding Project of Dongcheng District, Beijing
Objective To investigate the incidence and susceptibilities of non-fermenting bacteria isolates from Chinese respiratory (RTI), intra-abdominal (IAI) and urinary tract (UTI) infections to antimicrobial agents between 2015 and 2017. Methods In total, 3,246 non-fermentative bacteria were collected from 21 hospitals and 9 hospital departments across 7 regions of China. A central testing laboratory was employed to determine antimicrobial susceptibilities using appropriate standards of interpretation. Results The majority of the isolates wereAcinetobacter baumannii(n= 1,360, 41.9%) andPseudomonas aeruginosa(n= 1,341, 41.3%). Overall multidrug resistance (MDR) and carbapenem resistance (CR) rates ofAcinetobacter baumanniiwere 80.1 and 78.7% with MDR and CR rates in RTIs, IAIs, and UTIs of 82.0 and 81.0%, 82.6 and 81.0% as well as 53.1 and 46.9%. Overall MDR and CR rates ofPseudomonas aeruginosaisolates were 36.2 and 38.9% with 41.8 and 44.3%, 29.3 and 36.1% as well as 24.2 and 20.2% MDR and CR rates in RTIs, IAIs, and UTIs. Overall susceptibility rates to imipenem, meropenem, amikacin, ciprofloxacin, cefepime and piperacillin-tazobactam were 21.1, 21.3, 33.0, 18.4, 19.2, and 19.6% forAcinetobacter baumanniiand 56.5, 58.5, 88.4, 63.1, 63.1, and 55.63% forPseudomonas aeruginosaisolates, whereas for colistin they were 95.7 and 94.6%, respectively. In all departments and regions of China, susceptibility rates ofPseudomonas aeruginosaandAcinetobacter baumanniiisolates to colistin were constantly above 80%. Conclusion Due to the high MDR and CR rates forPseudomonas aeruginosaandAcinetobacter baumannii, isolates obtained from RTIs, IAIs, and UTIs only maintained high susceptibility rates to colistin between 2015 and 2017.
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