期刊
FRONTIERS IN MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.01902
关键词
host-defense peptide; innate immunity; homeostasis; toll-like receptor; self-antigen
类别
资金
- Canadian Institutes of Health Research (CIHR) [FDN-154287]
- Cystic Fibrosis Canada studentship [617081]
- UBC Killam Doctoral Scholar
- Consejo Nacional de Ciencia y Tecnologia (CONACYT) [595253]
- Emerging Leaders in the Americas Program (ELAP), through the Global Affairs Canada International Scholarships Program
Host-defense peptides (HDPs) are vital components of innate immunity in all vertebrates. While their antibacterial activity toward bacterial cells was the original focus for research, their ability to modulate immune and inflammatory processes has emerged as one of their major functions in the host and as a promising approach from which to develop novel therapeutics targeting inflammation and innate immunity. In this review, with particular emphasis on the cathelicidin family of peptides, the roles of natural HDPs are examined in managing immune activation, cellular recruitment, cytokine responses, and inflammation in response to infection, as well as their contribution(s) to various inflammatory disorders and autoimmune diseases. Furthermore, we discuss current efforts to develop synthetic HDPs as therapeutics aimed at restoring balance to immune responses that are dysregulated and contribute to disease pathologies.
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