期刊
ELIFE
卷 9, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.59422
关键词
-
类别
资金
- National Eye Institute [R00 EY026651, RO1 EY009339, R24 EY027283]
- International Retinal Research Foundation
- Research to Prevent Blindness
- Eye and Tissue Bank Foundation
- Finnish Cultural Foundation
- Orion Research Foundation
- Research to Prevent Blindness University of Utah
- Research to Prevent Blindness University of California
- Knights Templar Eye Foundation Career-Starter Research Grant
- Fight for Sight Postdoctoral Award
- NATIONAL EYE INSTITUTE [R01EY009339] Funding Source: NIH RePORTER
Neuronal plasticity of the inner retina has been observed in response to photoreceptor degeneration. Typically, this phenomenon has been considered maladaptive and may preclude vision restoration in the blind. However, several recent studies utilizing triggered photoreceptor ablation have shown adaptive responses in bipolar cells expected to support normal vision. Whether such homeostatic plasticity occurs during progressive photoreceptor degenerative disease to help maintain normal visual behavior is unknown. We addressed this issue in an established mouse model of Retinitis Pigmentosa caused by the P23H mutation in rhodopsin. We show robust modulation of the retinal transcriptomic network, reminiscent of the neurodevelopmental state, and potentiation of rod - rod bipolar cell signaling following rod photoreceptor degeneration. Additionally, we found highly sensitive night vision in P23H mice even when more than half of the rod photoreceptors were lost. These results suggest retinal adaptation leading to persistent visual function during photoreceptor degenerative disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据