期刊
CURRENT RHEUMATOLOGY REPORTS
卷 22, 期 11, 页码 -出版社
SPRINGER
DOI: 10.1007/s11926-020-00957-w
关键词
Fibroblast; Myofibroblast; Adipocyte; Fibrosis; Scleroderma; Adipose mesenchymal transition
类别
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [K08 AR070285]
Purpose of Review Adipocytes have recently been shown to be able to reprogram to a myofibroblastic phenotype in a process termed adipocyte mesenchymal transition (AMT). This review seeks to discuss the relevance of this process to disease and explore its mechanisms. Recent Findings AMT occurs in multiple organs and diseases, transdifferentiation goes through a precursor cell and there is a reversible process that can be influenced by metabolic stress, myeloid cells, immune dysregulation, and pharmacological intervention. AMT is a newly appreciated and highly relevant process in multiple forms of fibrosis. Targeting AMT may serve as a novel method of treating fibrosis.
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