期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 40, 期 -, 页码 74-80出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2016.06.007
关键词
-
资金
- Ontario Institute for Cancer Research (OICR
- New Investigator award) [IA-026]
- Canadian Institutes of Health Research (CIHR
- Banting and Best Doctoral student award) [GSD-140321]
Collectively, planarian stem cells (neoblasts) are totipotent and are required for tissue homeostasis and regeneration. Recent work has begun to test the long-standing question of whether all neoblasts have the same potential, or whether they actually represent molecularly distinct subpopulations with distinct tissue restriction. Here, we summarize the current state of the field in neoblast lineage organization. It is clear that at least some neoblasts are totipotent, whereas other neoblasts represent functionally distinct molecular subclasses with restricted potential. In addition to neoblast subclasses, tissue-specific progenitors have also been identified, though their ability to proliferate is largely unknown. Together, neoblast lineage development, subclasses, and cell hierarchies are becoming elucidated, showing the complex regulation required for proper tissue homeostasis and regeneration in planarians.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据